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CS-W001157 4
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2-Chloro-3-fluoro-4-hydroxypyridine

  • CAS No. 1184172-46-0

  • Cat. No. CS-0155598
  • Purity≥98%
  • MDL No.MFCD13189885

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-fluoro-4-hydroxypyridine|CS-0155598

Structure of 1184172-46-0

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General Information

  • CAS No. 1184172-46-0
  • Cat. No. CS-0155598
  • Purity ≥98%
  • MDL No. MFCD13189885
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFNO
  • Molecular Weight 147.53
  • Synonym(s) 2-Chloro-3-fluoropyridin-4-ol
  • SMILES C1=CN=C(C(=C1O)F)Cl

Description

2-Chloro-3-fluoro-4-hydroxypyridine features a strategically positioned hydroxyl group flanked by chlorine and fluorine substituents, enabling direct functionalization in heterocyclic synthesis. This electron-deficient pyridine scaffold integrates readily into bioactive molecules, offering enhanced reactivity for C–H activation and cross-coupling processes under mild conditions.

Application

2-Chloro-3-fluoro-4-hydroxypyridine serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the pyridine ring due to orthogonal reactivity of its chloro and fluoro substituents. The hydroxyl group provides a handle for derivatization or metal-catalyzed coupling reactions. Its bench-stable nature and compatibility with palladium-mediated cross-coupling protocols make it a practical choice for constructing complex pharmaceutical scaffolds and bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.5797
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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