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CS-W001157 4
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1-(Chloromethyl)-1,1,3,3,3-pentamethyldisiloxane

  • CAS No. 17201-83-1

  • Cat. No. CS-0186270
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Chloromethyl)-1,1,3,3,3-pentamethyldisiloxane|CS-0186270

Structure of 17201-83-1

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General Information

  • CAS No. 17201-83-1
  • Cat. No. CS-0186270
  • Purity ≥97%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₇ClOSi₂
  • Molecular Weight 196.82
  • Synonym(s) Chloromethylpentamethyldisiloxane
  • SMILES C[Si](C)(C)O[Si](C)(C)CCl

Description

This chloromethyl-functionalized disiloxane delivers a highly reactive electrophilic handle for silicon-directed conjugation. The pentamethyl-substituted framework imparts exceptional steric shielding and moisture tolerance, enabling reliable coupling under standard bench conditions.

Application

1-(Chloromethyl)-1,1,3,3,3-pentamethyldisiloxane serves as a robust, bench-stable silyl-protecting group reagent that enables selective functionalization of nucleophiles under mild conditions. Its sterically shielded disiloxane backbone enhances stability and minimizes side reactions, while the chloromethyl group facilitates efficient alkylation and downstream transformations. Ideal for constructing complex architectures in medicinal chemistry and materials science workflows.

Synthesis

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    • In-stock
      1-(Chloromethyl)-1,1,3,3,3-pentamethyldisiloxane|CS-0186270
      17201-83-1

    References

    • US2513924 , ; C. A., , p. 9978
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    • In-stock
      1-(Chloromethyl)-1,1,3,3,3-pentamethyldisiloxane|CS-0186270
      17201-83-1

    References

    • Journal of the American Chemical Society, , vol. 70, p. 3068,3070
  • Route3
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      5181-46-4
    • ~%
    • In-stock
      1-(Chloromethyl)-1,1,3,3,3-pentamethyldisiloxane|CS-0186270
      17201-83-1

    References

    • J. Gen. Chem. USSR (Engl. Transl.), , vol. 57, # 2 p. 375 - 382,323 - 330

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.821
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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