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CS-W001157 4
Total: USD 88.00

1-Isopropylthiourea

  • CAS No. 1719-76-2

  • Cat. No. CS-0180918
  • Molecule weight118.20
  • Purity≥98%
  • MDL No.MFCD00041375

*For research and further manufacturing use only, not for direct human use.

1-Isopropylthiourea|CS-0180918

Structure of 1719-76-2

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General Information

  • CAS No. 1719-76-2
  • Cat. No. CS-0180918
  • Purity ≥98%
  • MDL No. MFCD00041375
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀N₂S
  • Molecular Weight 118.20
  • Synonym(s) Urea, 1-isopropyl-2-thio-
  • SMILES S=C(N)NC(C)C

Description

1-Isopropylthiourea is a bench-stable thiourea derivative featuring a sterically hindered isopropyl group that enhances solubility in organic solvents. This configuration supports efficient coordination in catalytic systems and facilitates use in synthetic transformations requiring moderate nucleophilicity.

Application

1-Isopropylthiourea serves as a versatile sulfur-containing building block in synthetic organic chemistry, enabling efficient construction of thiazole and other heterocyclic scaffolds. Its amine-thioamide functionality facilitates nucleophilic substitution and condensation reactions under mild conditions, offering reliable access to medicinally relevant motifs. The molecule exhibits good bench stability and is compatible with common functional groups, simplifying purification and integration into multi-step syntheses.

Synthesis

  • Route1
    • N-t-butyl-n-isopropylthiourea|CS-0698055
      52599-24-3
    • ~89%
    • In-stock
      1-Isopropylthiourea|CS-0180918
      1719-76-2

    References

    • WO2005/73195 A2, ; Page/Page column 118 ; WO 2005/073195 A2
  • Route2
    • null|null
      2253-73-8
    • ~87%
    • In-stock
      1-Isopropylthiourea|CS-0180918
      1719-76-2

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 42, # 3 p. 698 - 701
  • Route3
    • null|null
      27248-16-4
    • ~%
    • In-stock
      1-Isopropylthiourea|CS-0180918
      1719-76-2

    References

    • Journal of the American Chemical Society, , vol. 70, p. 3455

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   0.228
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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