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Structure of 170147-76-9
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tert-Butyl 5-hydroxyindoline-1-carboxylate features a hydroxylated indoline core with a robust tert-butyl ester handle, enabling straightforward deprotection and functionalization. The molecule exhibits enhanced stability under standard bench conditions, facilitating its use in synthetic sequences requiring moisture-tolerant intermediates. This scaffold integrates readily into complex heterocyclic frameworks for medicinal chemistry applications.
tert-Butyl 5-hydroxyindoline-1-carboxylate serves as a versatile scaffold for the synthesis of indoline-based pharmaceutical intermediates. The hydroxyl group enables selective derivatization via esterification, etherification, or oxidation to quinone methides, while the tert-butyl carbamate offers orthogonal protection for nitrogen during multi-step sequences. Its bench-stable nature and compatibility with standard coupling and reduction conditions facilitate efficient access to medicinally relevant heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: