Lot numbers can be found on the outside label of a product:
tert-Butyl 5-hydroxyindoline-1-carboxylate
-
CAS No. 170147-76-9
- Cat. No. CS-0082129
- Purity≥97%
- MDL No.MFCD11045242
*For research and further manufacturing use only, not for direct human use.
Structure of 170147-76-9
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 170147-76-9
- Cat. No. CS-0082129
- Purity ≥97%
- MDL No. MFCD11045242
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₁₇NO₃
- Molecular Weight None
- Synonym(s) N-Boc-5-Hydroxyindoline
- SMILES O=C(N1CCC2=C1C=CC(O)=C2)OC(C)(C)C
Description
tert-Butyl 5-hydroxyindoline-1-carboxylate features a hydroxylated indoline core with a robust tert-butyl ester handle, enabling straightforward deprotection and functionalization. The molecule exhibits enhanced stability under standard bench conditions, facilitating its use in synthetic sequences requiring moisture-tolerant intermediates. This scaffold integrates readily into complex heterocyclic frameworks for medicinal chemistry applications.
Application
tert-Butyl 5-hydroxyindoline-1-carboxylate serves as a versatile scaffold for the synthesis of indoline-based pharmaceutical intermediates. The hydroxyl group enables selective derivatization via esterification, etherification, or oxidation to quinone methides, while the tert-butyl carbamate offers orthogonal protection for nitrogen during multi-step sequences. Its bench-stable nature and compatibility with standard coupling and reduction conditions facilitate efficient access to medicinally relevant heterocycles.
Synthesis
-
Route1
-
170147-29-2 - ~97%
-
In-stock
170147-76-9
References
-
Igarashi; Inami; Hara; Koutoku; Oritani; Mase Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 11 p. 1689 - 1697
-
-
Route2
-
273408-46-1 - ~89%
-
In-stock
170147-76-9
References
-
Stark, Lucy M.; Lin, Xiao-Fa; Flippin, Lee A. Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3227 - 3230
-
-
Route3
-
In-stock
24424-99-5 -
172078-33-0 - ~61%
-
In-stock
170147-76-9
References
-
BIOGEN IDEC MA INC.; THOMAS, Jermaine; LIU, Xiaogao; LIN, Edward, Yin-Shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin, M.; KUMARAVEL, Gnanasambandam; TAVERAS, Arthur, G. Patent: WO2011/17561 A1, 2011 ; Location in patent: Page/Page column 47 ; WO 2011/017561 A1
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H315-H319-H335
|
|
|
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 49.77
- LogP 2.6898
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 170147-76-9 sigma170147-76-9 manufacturer170147-76-9 price170147-76-9 structure170147-76-9 SDSbuy 170147-76-9170147-76-9 supplier170147-76-9 uses170147-76-9 molecular weightprice of 170147-76-9170147-76-9 chemical name formula of 170147-76-9