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CS-W001157 4
Total: USD 88.00

(2-(Benzyloxy)-4-(trifluoromethyl)phenyl)boronic acid

  • CAS No. 1701435-39-3

  • Cat. No. CS-0174009
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2-(Benzyloxy)-4-(trifluoromethyl)phenyl)boronic acid|CS-0174009

Structure of 1701435-39-3

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General Information

  • CAS No. 1701435-39-3
  • Cat. No. CS-0174009
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂BF₃O₃
  • Molecular Weight 296.05
  • Synonym(s) 2-Benzyloxy-4-(trifluoromethyl)phenylboronic acid
  • SMILES FC(F)(F)C1=CC(OCC2=CC=CC=C2)=C(B(O)O)C=C1

Description

This boronic acid features a benzyloxy group ortho to a trifluoromethyl-substituted phenyl ring, delivering enhanced stability and solubility in polar organic media. The electron-deficient arylboron moiety enables efficient Suzuki-Miyaura coupling under mild conditions, facilitating rapid assembly of complex biaryl architectures in medicinal chemistry and materials synthesis.

Application

(2-(Benzyloxy)-4-(trifluoromethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the benzyloxy functionality provides orthogonal protection and improved solubility. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing complex aryl scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   1.9642
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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