4-Chloro-2-cyclopropyl-6-fluoroquinazoline

Name: 4-Chloro-2-cyclopropyl-6-fluoroquinazoline
Brand: ChemScene
Availability: InStock
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CAS No. 1695621-65-8
Cat. No. CS-0160862
Purity≥97%
MDL No.MFCD28405377

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-2-cyclopropyl-6-fluoroquinazoline|CS-0160862

Structure of 1695621-65-8

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General Information

CAS No. 1695621-65-8
Cat. No. CS-0160862
Purity ≥97%
MDL No. MFCD28405377
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₈ClFN₂
Molecular Weight 222.65
Synonym(s) None
SMILES FC1=CC2=C(Cl)N=C(C3CC3)N=C2C=C1

Description

4-Chloro-2-cyclopropyl-6-fluoroquinazoline features a sterically hindered quinazoline core with electron-withdrawing chlorine and fluorine substituents, enabling robust integration into kinase inhibitor scaffolds. The cyclopropyl group enhances metabolic stability and membrane permeability, while the fused heterocyclic system provides a rigid platform for targeted molecular recognition in medicinal chemistry applications.

Application

4-Chloro-2-cyclopropyl-6-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. Its orthogonal functionalization sites—reactive chlorine at C4 and fluoro group at C6—facilitate palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, improving pharmacokinetic profiles. This compound exhibits excellent bench stability and is readily purified by chromatography, making it well-suited for high-throughput synthesis and API development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 3.2997
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

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4-Chloro-2-cyclopropyl-6-fluoroquinazoline

CAS No. 1695621-65-8

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