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CS-W001157 4
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8-Boc-3-oxo-2,8-diazaspiro[4.5]decane

  • CAS No. 169206-67-1

  • Cat. No. CS-B0188
  • Purity≥96%
  • MDL No.MFCD11111226

*For research and further manufacturing use only, not for direct human use.

8-Boc-3-oxo-2,8-diazaspiro[4.5]decane|CS-B0188

Structure of 169206-67-1

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General Information

  • CAS No. 169206-67-1
  • Cat. No. CS-B0188
  • Purity ≥96%
  • MDL No. MFCD11111226
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₂N₂O₃
  • Molecular Weight 254.33
  • Synonym(s) Tert-butyl3-oxo-2,8-diazaspiro[4,5]decane-8-carboxylate
  • SMILES O=C(OC(C)(C)C)N(CC1)CCC21CC(NC2)=O

Description

8-Boc-3-oxo-2,8-diazaspiro[4.5]decane delivers a sterically shielded, bench-stable spirocyclic scaffold featuring a protected amine and ketone functionality. This modular core integrates readily into complex heterocycles, enabling efficient access to bioactive nitrogen-containing frameworks under standard conditions.

Application

8-Boc-3-oxo-2,8-diazaspiro[4.5]decane serves as a versatile spirocyclic building block for medicinal chemistry and catalytic synthesis. The Boc-protected diamine moiety enables straightforward deprotection and functionalization, while the 3-oxo group facilitates nucleophilic addition and condensation reactions. Its rigid spiro scaffold provides conformational constraint ideal for target-oriented synthesis, with demonstrated stability and compatibility in standard organic transformations.

Synthesis

  • Route1
    • tert-Butyl 4-(2-methoxy-2-oxoethyl)-4-(nitromethyl)piperidine-1-carboxylate|CS-0732454
      169206-66-0
    • ~84%
    • In-stock
      8-Boc-3-oxo-2,8-diazaspiro[4.5]decane|CS-B0188
      169206-67-1

    References

    • Cumbre Inc. Patent: US2006/19985 A1, 2006 ; Location in patent: Page/Page column 55 ;
  • Route2
    • null|null
      79099-07-3
    • ~%
    • In-stock
      8-Boc-3-oxo-2,8-diazaspiro[4.5]decane|CS-B0188
      169206-67-1

    References

    • Journal of Medicinal Chemistry, , vol. 38, # 19 p. 3772 - 3779
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 38, # 19 p. 3772 - 3779

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.64
  • LogP   1.5236
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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