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CS-W001157 4
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2-Aminoquinazoline

  • CAS No. 1687-51-0

  • Cat. No. CS-W009159
  • Purity≥97%
  • MDL No.MFCD00956186

*For research and further manufacturing use only, not for direct human use.

2-Aminoquinazoline|CS-W009159

Structure of 1687-51-0

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General Information

  • CAS No. 1687-51-0
  • Cat. No. CS-W009159
  • Purity ≥97%
  • MDL No. MFCD00956186
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇N₃
  • Molecular Weight 145.16
  • Synonym(s) 2-Aminoquinazoline; Quinazolin-2-ylamine
  • SMILES NC1=NC=C2C=CC=CC2=N1

Description

2-Aminoquinazoline serves as a core scaffold in medicinal chemistry, offering a rigid, electron-rich heterocyclic platform for drug discovery. This bench-stable compound integrates readily into kinase inhibitors and targeted therapeutics, where its amino group enables direct functionalization and hydrogen bonding interactions critical to binding affinity.

Application

2-Aminoquinazoline serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to kinase inhibitors and other bioactive scaffolds. Its amino group facilitates direct functionalization and metal-catalyzed coupling reactions, while the quinazoline core exhibits favorable stability and solubility for downstream derivatization. The compound functions as a key intermediate in the synthesis of targeted therapeutics and is well-suited for parallel library generation due to its predictable reactivity and compatibility with standard synthetic protocols.

Synthesis

  • Route1

    References

    • Liu, Qing; Zhao, Yufen; Fu, Hua; Cheng, Changmei Synlett, 2013 , vol. 24, # 16 art. no. ST-2013-W0652-L, p. 2089 - 2094
  • Route2

    References

    • Journal of the Chemical Society, , p. 619,622 US2461950 , ;
  • Route3

    References

    • Huang, Xuhu; Yang, Haijun; Fu, Hua; Qiao, Renzhong; Zhao, Yufen Synthesis, 2009 , # 16 p. 2679 - 2688

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.212
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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