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CS-W001157 4
Total: USD 88.00

(2-Bromophenyl)methanamine

  • CAS No. 3959-05-5

  • Cat. No. CS-W004667
  • Purity≥97%
  • MDL No.MFCD00025572

*For research and further manufacturing use only, not for direct human use.

(2-Bromophenyl)methanamine|CS-W004667

Structure of 3959-05-5

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General Information

  • CAS No. 3959-05-5
  • Cat. No. CS-W004667
  • Purity ≥97%
  • MDL No. MFCD00025572
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrN
  • Molecular Weight 186.05
  • Synonym(s) 2-Bromobenzylamine
  • SMILES C1=C(C(=CC=C1)Br)CN

Description

(2-Bromophenyl)methanamine is a bench-stable arylalkyl amine featuring a bromine atom at the ortho position relative to the amino-methyl group. This substitution pattern enhances electrophilic reactivity while maintaining compatibility with palladium-catalyzed cross-coupling processes. The molecule integrates readily into complex heterocyclic scaffolds and serves as a key intermediate in pharmaceutical synthesis, particularly for bioactive compounds requiring spatially constrained aromatic frameworks.

Application

(2-Bromophenyl)methanamine serves as a versatile arylalkyl amine building block for medicinal chemistry and materials synthesis. The ortho-bromo substituent enables palladium-catalyzed cross-coupling reactions, while the primary amine facilitates salt formation, derivatization, and incorporation into heterocyclic scaffolds. Its bench-stable solid form and compatibility with standard purification protocols make it suitable for scalable synthetic workflows.

Synthesis

  • Route1
    • null|null
      2042-37-7
    • ~94%
    • In-stock
      (2-Bromophenyl)methanamine|CS-W004667
      3959-05-5

    References

    • Nabid, Mohammad Reza; Bide, Yasamin; Niknezhad, Mahvash ChemCatChem, 2014 , vol. 6, # 2 p. 538 - 546
  • Route2

    References

    • American Chemical Journal, , vol. 2, p. 317,319
  • Route3
    • null|null
      126799-87-9
    • ~93%
    • In-stock
      (2-Bromophenyl)methanamine|CS-W004667
      3959-05-5

    References

    • Prakasha, Kothathi C.; Sindhumol, Methatta; Ramesha Baba; Channe Gowda Journal of Chemical Research, 2007 , # 5 p. 284 - 286

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H312-H314-H318
Precautionary Statements : P260-P264-P270-P280-P301+P310-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.9078
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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