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2-Bromo-6-(hydroxymethyl)pyridin-3-ol

  • CAS No. 168015-04-1

  • Cat. No. CS-0320836
  • Molecule weight204.02
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-(hydroxymethyl)pyridin-3-ol|CS-0320836

Structure of 168015-04-1

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General Information

  • CAS No. 168015-04-1
  • Cat. No. CS-0320836
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO₂
  • Molecular Weight 204.02
  • Synonym(s) 2-bromo-6-(hydroxymethyl)pyridin-3-ol(WX191869)
  • SMILES C1=CC(=C(Br)N=C1CO)O

Description

2-Bromo-6-(hydroxymethyl)pyridin-3-ol features a pyridine core bearing a bromo group at the 2-position and a hydroxymethyl function at the 6-position, flanked by a phenolic hydroxyl at the 3-position. This trifunctional scaffold enables direct incorporation into heterocyclic architectures via cross-coupling or cyclization reactions under standard conditions. The molecule exhibits enhanced solubility in polar solvents and maintains stability during storage.

Application

2-Bromo-6-(hydroxymethyl)pyridin-3-ol serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyridine-based scaffolds through palladium-catalyzed coupling reactions. The pendant hydroxymethyl group offers orthogonal reactivity for derivatization, while the bromide facilitates cross-coupling under standard conditions. Bench-stable and compatible with common purification methods, it supports scalable workflows in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   1.042
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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