Lot numbers can be found on the outside label of a product:
2',4',6'-Trimethylacetophenone
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CAS No. 1667-01-2
- Cat. No. CS-0074269
- Purity≥95%
- MDL No.MFCD00008735
*For research and further manufacturing use only, not for direct human use.
Structure of 1667-01-2
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General Information
- CAS No. 1667-01-2
- Cat. No. CS-0074269
- Purity ≥95%
- MDL No. MFCD00008735
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₄O
- Molecular Weight 162.23
- Synonym(s) 2-Acetylmesitylene
- SMILES CC(C1=C(C)C=C(C)C=C1C)=O
Description
2',4',6'-Trimethylacetophenone features a sterically hindered acetyl group flanked by three methyl substituents, enhancing its stability and directing electrophilic substitution reactions. This electron-rich aryl ketone serves as a key building block in synthetic organic chemistry, particularly for constructing complex aromatic systems under mild conditions.
Application
2',4',6'-Trimethylacetophenone serves as a versatile building block in synthetic organic chemistry, leveraging its sterically hindered aryl ketone functionality for controlled electrophilic transformations. The methyl substituents enhance bench stability and facilitate purification by reducing side reactivity. It functions effectively in Friedel-Crafts acylations, Grignard additions, and as a precursor in heterocyclic scaffold construction, particularly in the synthesis of substituted benzophenones and biologically relevant aromatic systems.
Synthesis
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Route1
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In-stock
769-25-5 - ~74%
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In-stock
1667-01-2
References
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Wang, Yu-Fei; Gao, Ya-Ru; Mao, Shuai; Zhang, Yan-Lei; Guo, Dong-Dong; Yan, Zhao-Lei; Guo, Shi-Huan; Wang, Yong-Qiang Organic Letters, 2014 , vol. 16, # 6 p. 1610 - 1613
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Route2
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108-24-7 -
108-67-8
- ~97%
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In-stock
1667-01-2
References
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Chapman, Christopher J.; Frost, Christopher G.; Hartley, Joseph P.; Whittle, Alan J. Tetrahedron Letters, 2001 , vol. 42, # 5 p. 773 - 775
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Route3
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1517-71-1 - ~96%
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In-stock
1667-01-2
References
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Kuhakarn, Chutima; Kittigowittana, Krisada; Ghabkham, Pattama; Pohmakotr, Manat; Reutrakul, Vichai Synthetic Communications, 2006 , vol. 36, # 19 p. 2887 - 2892
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 17.07
- LogP 2.81446
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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