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CS-W001157 4
Total: USD 88.00

2,5-Dichloro-1,3-thiazole

  • CAS No. 16629-14-4

  • Cat. No. CS-0052142
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,5-Dichloro-1,3-thiazole|CS-0052142

Structure of 16629-14-4

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General Information

  • CAS No. 16629-14-4
  • Cat. No. CS-0052142
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃HCl₂NS
  • Molecular Weight 154.02
  • Synonym(s) 2,5-Dichlorothiazole
  • SMILES ClC1=CN=C(Cl)S1

Description

2,5-Dichloro-1,3-thiazole is a bench-stable, electron-deficient heterocycle featuring two chlorine substituents at the 2 and 5 positions. This configuration enhances its reactivity in nucleophilic substitution processes, enabling efficient incorporation into complex molecular architectures. The molecule’s rigid, planar structure supports its use as a building block in medicinal chemistry and materials science applications.

Application

2,5-Dichloro-1,3-thiazole serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient construction of bioactive heterocycles. Its dichloro substitution pattern enhances electrophilic reactivity at C2 and C5, facilitating nucleophilic displacement and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and compatibility with common functional groups, making it valuable for modular synthesis of pharmaceutical intermediates and agrochemical scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.4499
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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