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CS-W001157 4
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(4S,5S)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one

  • CAS No. 166275-25-8

  • Cat. No. CS-0447792
  • Molecule weight168.10
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4S,5S)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one|CS-0447792

Structure of 166275-25-8

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General Information

  • CAS No. 166275-25-8
  • Cat. No. CS-0447792
  • Purity ≥98%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆F₂O₄
  • Molecular Weight 168.10
  • Synonym(s) L-erythro-Pentonic acid, 2-deoxy-2,2-difluoro-,γ-lactone
  • SMILES C([C@H]1[C@@H](C(C(=O)O1)(F)F)O)O

Synthesis

  • Route1
    • Ethyl (R)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate|CS-1219540
      166376-98-3
    • ~%
    • (4S,5S)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one|CS-0447792
      166275-25-8

    References

    • Kotra, Lakshmi P.; Xiang, Yuejun; Gary Newton; Schinazi, Raymond F.; Cheng, Yung-C.; Chu, Chung K. Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3635 - 3644

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   66.76
  • LogP   -1.0997
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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