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CS-W001157 4
Total: USD 88.00

7-Bromo-1H-pyrrolo[2,3-c]pyridine

  • CAS No. 165669-35-2

  • Cat. No. CS-0043089
  • Purity≥96%
  • MDL No.MFCD03839909

*For research and further manufacturing use only, not for direct human use.

7-Bromo-1H-pyrrolo[2,3-c]pyridine|CS-0043089

Structure of 165669-35-2

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General Information

  • CAS No. 165669-35-2
  • Cat. No. CS-0043089
  • Purity ≥96%
  • MDL No. MFCD03839909
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrN₂
  • Molecular Weight 197.03
  • Synonym(s) 1H-Pyrrolo[2,3-c]pyridine, 7-bromo-
  • SMILES BrC1=NC=CC2=C1NC=C2

Description

7-Bromo-1H-pyrrolo[2,3-c]pyridine is a heterocyclic building block featuring a bromine substituent at the 7-position of a fused pyrrolopyridine core. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions, facilitating access to complex pharmaceutical intermediates and advanced materials under standard conditions.

Application

7-Bromo-1H-pyrrolo[2,3-c]pyridine serves as a versatile heterocyclic building block in medicinal chemistry and cross-coupling synthesis. The bromine substituent enables reliable Suzuki, Stille, and Negishi couplings, facilitating the construction of biaryl and extended π-conjugated systems. Its stability under standard reaction conditions and compatibility with diverse functional groups make it well-suited for iterative synthetic strategies in API development and target-oriented synthesis.

Synthesis

  • Route1
    • In-stock
      2-Bromo-3-nitropyridine|CS-W015483
      19755-53-4
    • null|null
      1826-67-1
    • ~61%
    • In-stock
      7-Bromo-1H-pyrrolo[2,3-c]pyridine|CS-0043089
      165669-35-2

    References

    • WO2011/19634 A2, ; Page/Page column 13 ;
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 56, # 20 p. 8008 - 8018

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2923
Class : 8 (6.1)
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.3254
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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