Tert-butyl 4-(3-chloropropyl)piperazine-1-carboxylate

Name: Tert-butyl 4-(3-chloropropyl)piperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 165530-45-0
Cat. No. CS-0237903
Purity≥97%
MDL No.MFCD10697871

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Tert-butyl 4-(3-chloropropyl)piperazine-1-carboxylate|CS-0237903

Structure of 165530-45-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 165530-45-0
Cat. No. CS-0237903
Purity ≥97%
MDL No. MFCD10697871
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₃ClN₂O₂
Molecular Weight 262.78
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CCN(CC1)CCCCl

Description

Tert-butyl 4-(3-chloropropyl)piperazine-1-carboxylate is a bench-stable, moisture-tolerant piperazine derivative featuring a reactive chloroalkyl side chain. This functional group enables efficient coupling in amine-directed transformations, facilitating the synthesis of bioactive molecules through nucleophilic substitution. The tert-butyl ester serves as a protective handle for subsequent deprotection under mild acidic conditions.

Application

Tert-butyl 4-(3-chloropropyl)piperazine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the introduction of piperazine-linked alkyl chains with controlled reactivity. The chloropropyl side chain facilitates nucleophilic substitution reactions, while the tert-butyl carbamate group offers stability and convenient deprotection under mild acidic conditions. This combination supports efficient synthesis of complex heterocyclic scaffolds and functionalized analogs relevant to drug discovery workflows.

Synthesis

Route1
- In-stock
  
  6940-76-7
- 57260-71-6
- ~47%
- In-stock
  
  165530-45-0
References
- SMITHKLINE BEECHAM CORPORATION Patent: WO2006/20415 A1, 2006 ; Location in patent: Page/Page column 67 ; WO 2006/020415 A1
Route2
- 109-70-6
- 57260-71-6
- ~%
- In-stock
  
  165530-45-0
References
- GE HEALTHCARE LIMITED; MEDI-PHYSICS, INC.; NEWINGTON, Ian, Martin; WYNN, Duncan George; NAIRNE, Robert James Domett; GUILBERT, Benedicte; MANDAL, Subrata; JINTO, Jose; VARADARAJAN, Sunderaraman; RANGASWAMY, Chitralekha; BETTS, Helen; DAVIS, Rebecca Patent: WO2011/150183 A1, 2011 ; Location in patent: Page/Page column 66; 68 ; WO 2011/150183 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 1760
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 32.78
LogP 2.168
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

165530-45-0 sigma165530-45-0 manufacturer165530-45-0 price165530-45-0 structure165530-45-0 SDSbuy 165530-45-0165530-45-0 supplier165530-45-0 uses165530-45-0 molecular weightprice of 165530-45-0165530-45-0 chemical name formula of 165530-45-0

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Tert-butyl 4-(3-chloropropyl)piperazine-1-carboxylate

CAS No. 165530-45-0

Recommended Products