tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate

Name: tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 655225-02-8
Cat. No. CS-0119889
Purity≥96%
MDL No.MFCD09029312

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate|CS-0119889

Structure of 655225-02-8

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General Information

CAS No. 655225-02-8
Cat. No. CS-0119889
Purity ≥96%
MDL No. MFCD09029312
Storage -20°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₃BrN₂O₂
Molecular Weight 307.23
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CCN(CC1)CCCBr

Description

tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate features a bromoalkyl chain enabling efficient coupling reactions. This bench-stable, moisture-tolerant reagent integrates readily into synthetic workflows, delivering piperazine scaffolds with high functional group compatibility.

Application

tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate serves as a versatile bifunctional building block, enabling efficient installation of piperazine scaffolds via nucleophilic substitution. The bromide moiety facilitates coupling with diverse nucleophiles, while the tert-butoxycarbonyl group provides stable protection for piperazine nitrogen, allowing straightforward deprotection under mild acidic conditions. Its bench-stable, crystalline form supports reliable handling and purification in multi-step synthesis.

Synthesis

Route1
- In-stock
  
  109-64-8
- 57260-71-6
- ~78%
- In-stock
  
  655225-02-8
References
- Baraldi, Pier Giovanni; Romagnoli, Romeo; Nunez, Maria Del Carmen; Perretti, Mauro; Paul-Clark, Mark J.; Ferrario, Massimiliano; Govoni, Mirco; Benedini, Francesca; Ongini, Ennio Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 711 - 719
Route2
- In-stock
  
  132710-90-8
- ~%
- In-stock
  
  655225-02-8
References
- WO2009/10491 A1, ; Page/Page column 56 ; WO 2009/010491 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 32.78
LogP 2.3241
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

655225-02-8 sigma655225-02-8 manufacturer655225-02-8 price655225-02-8 structure655225-02-8 SDSbuy 655225-02-8655225-02-8 supplier655225-02-8 uses655225-02-8 molecular weightprice of 655225-02-8655225-02-8 chemical name formula of 655225-02-8

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tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate

CAS No. 655225-02-8

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