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CS-W001157 4
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tert-Butyl 4-(3-bromopropyl)piperidine-1-carboxylate

  • CAS No. 164149-27-3

  • Cat. No. CS-0187677
  • Purity≥97%
  • MDL No.MFCD23701754

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(3-bromopropyl)piperidine-1-carboxylate|CS-0187677

Structure of 164149-27-3

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General Information

  • CAS No. 164149-27-3
  • Cat. No. CS-0187677
  • Purity ≥97%
  • MDL No. MFCD23701754
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₄BrNO₂
  • Molecular Weight 306.24
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(CC1)CCCBr

Description

tert-Butyl 4-(3-bromopropyl)piperidine-1-carboxylate features a bromoalkyl chain appended to a piperidine nitrogen, enabling direct functionalization in synthetic sequences. The tert-butyl carbamate group provides stability and ease of deprotection under mild acidic conditions. This reagent facilitates the construction of complex amine-containing architectures in medicinal chemistry and materials science.

Application

tert-Butyl 4-(3-bromopropyl)piperidine-1-carboxylate serves as a versatile bifunctional building block for medicinal chemistry and process development. The piperidine nitrogen is protected as a stable tert-butyl carbamate, while the terminal bromide enables efficient SN2 reactions, including coupling with nucleophiles, palladium-catalyzed cross-couplings, or incorporation into heterocyclic scaffolds. Its bench-stable nature and ease of purification make it ideal for multi-step synthesis workflows requiring selective functionalization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   3.8086
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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