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CS-W001157 4
Total: USD 88.00

3-(Thiophen-3-yl)propanoic acid

  • CAS No. 16378-06-6

  • Cat. No. CS-0043393
  • Purity≥97%
  • MDL No.MFCD06655385

*For research and further manufacturing use only, not for direct human use.

3-(Thiophen-3-yl)propanoic acid|CS-0043393

Structure of 16378-06-6

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General Information

  • CAS No. 16378-06-6
  • Cat. No. CS-0043393
  • Purity ≥97%
  • MDL No. MFCD06655385
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈O₂S
  • Molecular Weight 156.20
  • Synonym(s) 3-THIEN-3-YLPROPANOIC ACID
  • SMILES O=C(O)CCC1=CSC=C1

Description

This thiophene-containing carboxylic acid integrates a conjugated heterocyclic scaffold with a flexible aliphatic chain, enabling efficient incorporation into bioactive molecules. The para-positioned thiophene ring enhances π-stacking and electronic modulation, while the terminal carboxyl group facilitates derivatization via amide coupling or esterification under standard conditions.

Application

3-(Thiophen-3-yl)propanoic acid serves as a versatile building block for synthesizing bioactive heterocycles and pharmaceutical intermediates. Its conjugated thiophene–alkyl carboxylic acid motif enables reliable coupling reactions, including amide formation and esterification, with excellent functional group tolerance. The compound exhibits good bench stability and is readily purified by recrystallization, facilitating its use in scalable synthetic routes.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.7653
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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