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CS-W001157 4
Total: USD 88.00

(3'R)-Ezetimibe

  • CAS No. 163380-16-3

  • Cat. No. CS-0113105
  • Purity≥98%
  • MDL No.MFCD00937873

*For research and further manufacturing use only, not for direct human use.

(3'R)-Ezetimibe|CS-0113105

Structure of 163380-16-3

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General Information

  • CAS No. 163380-16-3
  • Cat. No. CS-0113105
  • Purity ≥98%
  • MDL No. MFCD00937873
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₁F₂NO₃
  • Molecular Weight 409.43
  • Synonym(s) (3'R)-SCH 58235; (3R,4S)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
  • SMILES O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@H](C4=CC=C(F)C=C4)O

Synthesis

  • Route1

    References

    • US2006/69080 A1, ; Page/Page column 27 ;
  • Route2

    References

    • US2005/96307 A1, ; Page/Page column 24 ;
  • Route3
    • Ezetimibe Impurity 72|CS-1001851
      163380-15-2
    • ~%
    • (3'R)-Ezetimibe|CS-0113105
      163380-16-3

    References

    • Journal of Medicinal Chemistry, , vol. 41, # 6 p. 973 - 980

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   60.77
  • LogP   4.8883
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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