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CS-W001157 4
Total: USD 88.00

(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one

  • CAS No. 163222-32-0

  • Cat. No. CS-0140352
  • Purity≥97%
  • MDL No.MFCD00937870

*For research and further manufacturing use only, not for direct human use.

(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one|CS-0140352

Structure of 163222-32-0

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General Information

  • CAS No. 163222-32-0
  • Cat. No. CS-0140352
  • Purity ≥97%
  • MDL No. MFCD00937870
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₁H₂₇F₂NO₃
  • Molecular Weight 499.55
  • Synonym(s) Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-Hydroxypropyl]-4-[4-(Phenylmethoxy)phenyl]-, (3R,4S)-
  • SMILES O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(OCC4=CC=CC=C4)C=C3)[C@H]1CC[C@@H](C5=CC=C(F)C=C5)O

Synthesis

  • Route1

    References

    • TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC. Patent: WO2007/30721 A2, 2007 ; Location in patent: Page/Page column 23; 24; 27 ;
  • Route2
    • null|null
      1412967-16-8
    • null|null
      352-13-6
    • ~%
    • In-stock
      (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one|CS-0140352
      163222-32-0

    References

    • WO2012/155932 A1, ; Page/Page column 11 ;
  • Route3
    • Ezetimibe Impurity 140|CS-1001848
      163222-31-9
    • ~%
    • In-stock
      (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one|CS-0140352
      163222-32-0

    References

    • WO2006/60461 A1, ; Page/Page column 305 ; WO 2006/060461 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   6.7617
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   9

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