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CS-W001157 4
Total: USD 88.00

2-[(4S)-4,5-Dihydro-4-(phenylmethyl)-2-oxazolyl]phenol

  • CAS No. 163165-92-2

  • Cat. No. CS-0645863
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-[(4S)-4,5-Dihydro-4-(phenylmethyl)-2-oxazolyl]phenol|CS-0645863

Structure of 163165-92-2

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General Information

  • CAS No. 163165-92-2
  • Cat. No. CS-0645863
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₅NO₂
  • Molecular Weight 253.30
  • Synonym(s) None
  • SMILES OC1=C(C2=N[C@@H](CC3=CC=CC=C3)CO2)C=CC=C1

Description

This oxazolylphenol integrates a sterically protected oxazole ring with a phenolic hydroxyl, enabling stable coupling in late-stage functionalization. The dihydrooxazole moiety enhances solubility and metabolic stability, while the para-phenylmethyl group confers rigidity and electron-rich character. This scaffold facilitates direct C–H arylation and serves as a key building block in bioactive heterocycle synthesis.

Application

2-[(4S)-4,5-Dihydro-4-(phenylmethyl)-2-oxazolyl]phenol serves as a versatile chiral building block in synthetic medicinal chemistry, enabling access to oxazoline-containing scaffolds via standard coupling and cyclization protocols. Its bench-stable nature, functional group tolerance, and defined stereochemistry facilitate reliable incorporation into complex heterocyclic systems. The molecule functions effectively in transition-metal-catalyzed transformations and provides orthogonal reactivity for downstream derivatization in API synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   41.82
  • LogP   2.7803
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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