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CS-W001157 4
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Benzyldimethylsilane

  • CAS No. 1631-70-5

  • Cat. No. CS-0129591
  • Purity≥97%
  • MDL No.MFCD30213724

*For research and further manufacturing use only, not for direct human use.

Benzyldimethylsilane|CS-0129591

Structure of 1631-70-5

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General Information

  • CAS No. 1631-70-5
  • Cat. No. CS-0129591
  • Purity ≥97%
  • MDL No. MFCD30213724
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄Si
  • Molecular Weight None
  • Synonym(s) Silane, dimethyl(phenylmethyl)-
  • SMILES C[SiH](CC1=CC=CC=C1)C

Description

Benzyldimethylsilane delivers a robust, bench-stable silane handle for direct functionalization in synthetic workflows. This moisture-tolerant reagent features a benzyl-protected silicon center, enabling selective transformations under mild conditions. The aromatic moiety enhances solubility and stability, while the dimethyl substitution ensures low reactivity until activation. Ideal for coupling sequences requiring controlled silyl group introduction.

Application

Benzyldimethylsilane serves as a reliable silyl protecting group for alcohols and thiols, offering excellent stability under a wide range of reaction conditions. It enables selective protection and subsequent deprotection with mild fluoride sources, facilitating efficient synthetic sequences in complex molecule assembly. Its bench-stable nature and compatibility with diverse functional groups make it a practical choice for medicinal chemistry and process-scale applications.

Synthesis

  • Route1
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      1833-31-4
    • ~%
    • In-stock
      Benzyldimethylsilane|CS-0129591
      1631-70-5

    References

    • Journal of the American Chemical Society, , vol. 83, p. 1916 - 1921
  • Route2
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      10025-78-2
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      676-58-4
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      6921-34-2
    • ~17%
    • In-stock
      Benzyldimethylsilane|CS-0129591
      1631-70-5

    References

    • Jenkins, J. W.; Post, H. W. Journal of Organic Chemistry, 1950 , vol. 15, p. 552 - 555 Full Text View citing articles Show Details Gmelin Handbook: Si: MVol.C, 36, page 111 - 115
  • Route3
    • null|null
      6921-34-2
    • ~%
    • In-stock
      Benzyldimethylsilane|CS-0129591
      1631-70-5

    References

    • Journal of Organic Chemistry, , vol. 15, p. 552,554

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.255
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   2

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