tert-Butyl ((3R,4S)-3-fluoropiperidin-4-yl)carbamate

Name: tert-Butyl ((3R,4S)-3-fluoropiperidin-4-yl)carbamate
Brand: ChemScene
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CAS No. 1630815-57-4
Cat. No. CS-0058555
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl ((3R,4S)-3-fluoropiperidin-4-yl)carbamate|CS-0058555

Structure of 1630815-57-4

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General Information

CAS No. 1630815-57-4
Cat. No. CS-0058555
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₉FN₂O₂
Molecular Weight 218.27
Synonym(s) tert-butyl N-[(3R,4S)-3-fluoropiperidin-4-yl]carbamate
SMILES F[C@H]1[C@@H](NC(OC(C)(C)C)=O)CCNC1

Description

This tert-butyl ((3R,4S)-3-fluoropiperidin-4-yl)carbamate features a stereochemically defined fluorinated piperidine core with enhanced metabolic stability. The protected amine facilitates direct incorporation into complex scaffolds without epimerization. Its bench-stable nature enables straightforward handling in multi-step synthesis and process development workflows.

Application

tert-Butyl ((3R,4S)-3-fluoropiperidin-4-yl)carbamate serves as a stereochemically defined building block for fluorinated piperidine scaffolds in medicinal chemistry. The (3R,4S) configuration provides consistent stereocontrol in downstream transformations, while the tert-butyl carbamate group offers bench stability and convenient deprotection under mild acidic conditions. It functions as a key intermediate in the synthesis of bioactive molecules, particularly those requiring fluorinated heterocycles with enhanced metabolic stability and membrane permeability.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 50.36
LogP 1.2111
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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tert-Butyl ((3R,4S)-3-fluoropiperidin-4-yl)carbamate

CAS No. 1630815-57-4

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