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CS-W001157 4
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5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine Trimethoprim Impurity

  • CAS No. 16285-82-8

  • Cat. No. CS-0531859
  • Molecule weight339.19
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine Trimethoprim Impurity|CS-0531859

Structure of 16285-82-8

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General Information

  • CAS No. 16285-82-8
  • Cat. No. CS-0531859
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₅BrN₄O₂
  • Molecular Weight 339.19
  • Synonym(s) Trimethoprim impurity F
  • SMILES BrC1=C(OC)C(OC)=CC(CC2=CN=C(N)N=C2N)=C1

Description

5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine serves as a critical impurity reference standard in the synthesis and quality control of trimethoprim. This compound features a brominated dimethoxybenzyl substituent attached to a pyrimidine-2,4-diamine core, exhibiting enhanced stability under standard handling conditions. Its well-defined structure enables accurate detection and quantification in pharmaceutical development workflows.

Application

5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine serves as a well-characterized impurity in trimethoprim synthesis, enabling accurate method development and quality control in pharmaceutical assays. Its stable pyrimidine core with orthogonal diamine and brominated benzyl functionalities facilitates targeted derivatization and chromatographic monitoring. The compound exhibits predictable reactivity in standard coupling and purification workflows, supporting its use in reference material preparation and process analytical testing.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   96.28
  • LogP   2.0115
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   4

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