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CS-W001157 4
Total: USD 88.00

4′-DTMP

  • CAS No. 21253-58-7

  • Cat. No. CS-0643565
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4′-DTMP|CS-0643565

Structure of 21253-58-7

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General Information

  • CAS No. 21253-58-7
  • Cat. No. CS-0643565
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₆N₄O₃
  • Molecular Weight 276.29
  • Synonym(s) None
  • SMILES OC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1OC

Description

4′-DTMP is a bench-stable, moisture-tolerant nucleoside analog featuring a protected 3′-hydroxyl group and a modified sugar ring. This configuration enables direct incorporation into oligonucleotide chains without requiring additional activation steps, streamlining synthesis in automated platforms. The compound pairs effectively with standard phosphoramidite chemistry to deliver high coupling efficiency and sequence fidelity.

Application

4′-DTMP serves as a key building block in nucleoside synthesis, enabling efficient construction of deoxyribonucleoside analogs through standard glycosylation protocols. Its stable 2′,3′-diol configuration and protected hydroxyl groups facilitate selective coupling reactions, while the phosphate functionality supports downstream phosphorylation steps critical for antiviral and anticancer prodrug development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   116.51
  • LogP   0.9546
  • H_Acceptors   7
  • H_Donors   3
  • Rotatable_Bonds   4

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