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CS-W001157 4
Total: USD 88.00

Rimonabant carboxylic acid

  • CAS No. 162758-35-2

  • Cat. No. CS-0143479
  • Purity≥98%
  • MDL No.MFCD06411080

*For research and further manufacturing use only, not for direct human use.

Rimonabant carboxylic acid|CS-0143479

Structure of 162758-35-2

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General Information

  • CAS No. 162758-35-2
  • Cat. No. CS-0143479
  • Purity ≥98%
  • MDL No. MFCD06411080
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₁Cl₃N₂O₂
  • Molecular Weight 381.64
  • Synonym(s) Rimonabat acomplia
  • SMILES O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(Cl)C=C3)=C1C)O

Description

Rimonabant carboxylic acid features a polar, bench-stable carboxylate group enabling direct conjugation in bioconjugation workflows. This derivative retains the core pharmacophore of rimonabant, offering enhanced solubility and reactivity for targeted probe development in cannabinoid receptor studies.

Application

Rimonabant carboxylic acid serves as a key synthetic intermediate for cannabinoid receptor modulators, enabling straightforward derivatization via standard amide and ester formation protocols. Its carboxylic acid functionality offers high reactivity in coupling reactions with amines and alcohols, facilitating rapid access to analogs. The compound exhibits excellent bench stability and clean purification profiles, making it well-suited for medicinal chemistry screening campaigns and API scaffold development.

Synthesis

  • Route1
    • null|null
      158941-22-1
    • ~98%
    • In-stock
      Rimonabant carboxylic acid|CS-0143479
      162758-35-2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 5 p. 1151 - 1154
  • Route2
    • null|null
      170937-37-8
    • ~92%
    • In-stock
      Rimonabant carboxylic acid|CS-0143479
      162758-35-2

    References

    • Synthetic Communications, , vol. 44, # 1 p. 32 - 41
  • Route3
    • null|null
      192702-54-8
    • In-stock
      1-Bromo-2,4-dichlorobenzene|CS-W013035
      1193-72-2
    • ~%
    • In-stock
      Rimonabant carboxylic acid|CS-0143479
      162758-35-2

    References

    • WO2008/101860 A1, ; Page/Page column 7 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   5.50612
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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