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CS-W001157 4
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Methyl azetidine-2-carboxylate hydrochloride

  • CAS No. 162698-26-2

  • Cat. No. CS-W018690
  • Purity≥95%
  • MDL No.MFCD01861757

*For research and further manufacturing use only, not for direct human use.

Methyl azetidine-2-carboxylate hydrochloride|CS-W018690

Structure of 162698-26-2

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General Information

  • CAS No. 162698-26-2
  • Cat. No. CS-W018690
  • Purity ≥95%
  • MDL No. MFCD01861757
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀ClNO₂
  • Molecular Weight 151.59
  • Synonym(s) RS-2-Azetidinecarboxylic acid methyl ester hydrochloride
  • SMILES O=C(C1NCC1)OC.[H]Cl

Description

Methyl azetidine-2-carboxylate hydrochloride delivers a strained, electron-rich heterocyclic scaffold ideal for peptide synthesis and medicinal chemistry. This bench-stable salt features enhanced solubility and controlled reactivity, enabling efficient incorporation into bioactive molecules. The protected amine facilitates selective derivatization, streamlining the construction of conformationally constrained analogs.

Application

Methyl azetidine-2-carboxylate hydrochloride serves as a synthetically versatile building block for bioactive heterocycles, enabling efficient access to peptidomimetics and pharmaceutical scaffolds. Its constrained azetidine ring imparts enhanced metabolic stability and conformational rigidity, while the ester functionality facilitates selective derivatization. The hydrochloride salt enhances bench stability and solubility in polar solvents, simplifying handling and purification in standard synthetic workflows.

Synthesis

  • Route1
    • (S)-1-methylazetidine-2-carboxylic acid|CS-0052023
      255882-95-2
    • ~%
    • In-stock
      Methyl azetidine-2-carboxylate hydrochloride|CS-W018690
      162698-26-2

    References

    • Ortho-McNeil Pharmaceutical, Inc. Patent: US6544976 B1, 2003 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   -0.0569
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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