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CS-W001157 4
Total: USD 88.00

3-Bromo-1-cyclopropyl-1H-pyrazole

  • CAS No. 1622840-18-9

  • Cat. No. CS-0373602
  • Molecule weight187.04
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-1-cyclopropyl-1H-pyrazole|CS-0373602

Structure of 1622840-18-9

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General Information

  • CAS No. 1622840-18-9
  • Cat. No. CS-0373602
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂
  • Molecular Weight 187.04
  • Synonym(s) None
  • SMILES BrC1=NN(C2CC2)C=C1

Description

3-Bromo-1-cyclopropyl-1H-pyrazole is a bench-stable heterocyclic building block featuring a bromine atom at the 3-position and a cyclopropyl group attached to nitrogen. This configuration enables direct functionalization in cross-coupling reactions, offering efficient access to substituted pyrazole scaffolds with tailored steric and electronic profiles.

Application

3-Bromo-1-cyclopropyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the bromine site. The cyclopropyl group enhances metabolic stability and modulates lipophilicity, while the pyrazole core provides hydrogen-bonding capability and structural rigidity. This compound exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in standard coupling protocols for constructing complex heterocyclic scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   1.9805
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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