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(2R,6R)-2,6-Dimethylpiperazine dihydrochloride

  • CAS No. 162240-93-9

  • Cat. No. CS-0001868
  • Purity≥97%
  • MDL No.MFCD13193063

*For research and further manufacturing use only, not for direct human use.

(2R,6R)-2,6-Dimethylpiperazine dihydrochloride|CS-0001868

Structure of 162240-93-9

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General Information

  • CAS No. 162240-93-9
  • Cat. No. CS-0001868
  • Purity ≥97%
  • MDL No. MFCD13193063
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₆Cl₂N₂
  • Molecular Weight 187.11
  • Synonym(s) Piperazine, 2,6-diMethyl-, (dihydrochloride), (2R-trans)-)
  • SMILES C[C@H]1N[C@H](C)CNC1.Cl.Cl

Description

This bench-stable dihydrochloride salt features a rigid, electron-deficient piperazine core with defined stereochemistry at the 2- and 6-positions. The dimethyl substitution enhances lipophilicity and metabolic stability, while the paired chloride ions ensure excellent solubility in aqueous media. This compound serves as a key chiral building block for medicinal chemistry applications requiring controlled basicity and enhanced membrane permeability.

Application

(2R,6R)-2,6-Dimethylpiperazine dihydrochloride serves as a chiral building block for medicinal chemistry and catalyst design, offering enhanced stability and defined stereochemistry. Its diamine functionality facilitates efficient coupling reactions, while the protonated form ensures solubility and ease of purification in aqueous/organic workflows. Functions reliably in asymmetric synthesis and as a scaffold for bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   24.06
  • LogP   0.7998
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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