Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Pyrazole-3-carboxylic acid

  • CAS No. 1621-91-6

  • Cat. No. CS-W002328
  • Purity≥98%
  • MDL No.MFCD00077436

*For research and further manufacturing use only, not for direct human use.

Pyrazole-3-carboxylic acid|CS-W002328

Structure of 1621-91-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 1621-91-6
  • Cat. No. CS-W002328
  • Purity ≥98%
  • MDL No. MFCD00077436
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄N₂O₂
  • Molecular Weight 112.09
  • Synonym(s) None
  • SMILES O=C(C1=NNC=C1)O

Description

Pyrazole-3-carboxylic acid features a rigid heterocyclic core with a carboxylic acid group at the 3-position, enabling direct conjugation in bioactive molecule design. The electron-deficient pyrazole ring facilitates hydrogen bonding and dipole interactions, enhancing target affinity in medicinal chemistry applications. This bench-stable derivative integrates readily into scaffold-hopping strategies and serves as a key building block for kinase inhibitors and receptor modulators.

Application

Pyrazole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds through standard amide coupling and derivatization protocols. Its carboxylic acid functionality facilitates direct conjugation with amines, while the pyrazole ring provides metabolic stability and hydrogen-bonding capacity. The compound exhibits excellent bench stability and is compatible with common purification methods, making it well-suited for high-throughput screening campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • BIOLIPOX AB; MCNEENEY, Stephen, Phillip Patent: WO2004/80999 A1, 2004 ; Location in patent: Page 43 ;
  • Route2

    References

    • Almirall, S.A.; Eastwood, Paul Robert; Gonzalez Rodriguez, Jacob; Bach Taña, Jordi; Pages Santacana, Lluis Miquel; Taltavull Moll, Joan; Caturla Javaloyes, Juan Francisco Patent: EP2338888 A1, 2011 ; Location in patent: Paragraph 0215; 0216 ; EP 2338888 A1
  • Route3

    References

    • Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L. Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   65.98
  • LogP   0.1079
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Pyrazole-3-carboxylic acid sigmaPyrazole-3-carboxylic acid manufacturerPyrazole-3-carboxylic acid pricePyrazole-3-carboxylic acid structurePyrazole-3-carboxylic acid SDSbuy Pyrazole-3-carboxylic acidPyrazole-3-carboxylic acid supplierPyrazole-3-carboxylic acid usesPyrazole-3-carboxylic acid molecular weightprice of Pyrazole-3-carboxylic acidPyrazole-3-carboxylic acid chemical name formula of Pyrazole-3-carboxylic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label