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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(chlorosulfonyl)piperazine-1-carboxylate

  • CAS No. 162046-65-3

  • Cat. No. CS-0208153
  • Purity≥97%
  • MDL No.MFCD09971637

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(chlorosulfonyl)piperazine-1-carboxylate|CS-0208153

Structure of 162046-65-3

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General Information

  • CAS No. 162046-65-3
  • Cat. No. CS-0208153
  • Purity ≥97%
  • MDL No. MFCD09971637
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₇ClN₂O₄S
  • Molecular Weight 284.76
  • Synonym(s) None
  • SMILES CC(C)(C)OC(=O)N1CCN(CC1)S(=O)(=O)Cl

Description

tert-Butyl 4-(chlorosulfonyl)piperazine-1-carboxylate features a reactive chlorosulfonyl group enabling direct sulfonamide formation. This bench-stable, moisture-tolerant reagent integrates readily into synthetic sequences requiring piperazine-based scaffolds. The tert-butyl ester offers convenient protection and subsequent deprotection under mild acidic conditions.

Application

tert-Butyl 4-(chlorosulfonyl)piperazine-1-carboxylate serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles. Its chlorosulfonyl group enables efficient nucleophilic substitution with amines, facilitating the construction of piperazine-based scaffolds common in medicinal chemistry. The tert-butoxycarbonyl (Boc) group provides stability and ease of removal under mild acidic conditions, enhancing purification and functional group compatibility in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   66.92
  • LogP   1.0227
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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