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CS-W001157 4
Total: USD 88.00

Ethyl 2-(diphenoxyphosphoryl)acetate

  • CAS No. 16139-79-0

  • Cat. No. CS-0041016
  • Purity≥95%
  • MDL No.MFCD01321165

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(diphenoxyphosphoryl)acetate|CS-0041016

Structure of 16139-79-0

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General Information

  • CAS No. 16139-79-0
  • Cat. No. CS-0041016
  • Purity ≥95%
  • MDL No. MFCD01321165
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₇O₅P
  • Molecular Weight None
  • Synonym(s) Diphenylphosphonoacetic Acid Ethyl Ester
  • SMILES O=C(OCC)CP(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O

Description

Ethyl 2-(diphenoxyphosphoryl)acetate features a phosphonyl group flanked by two phenyl rings, delivering high stability and compatibility in phosphorylation reactions. This bench-stable reagent integrates efficiently into synthetic pathways requiring controlled P–C bond formation, enabling precise construction of phosphate ester motifs under standard conditions.

Application

Ethyl 2-(diphenoxyphosphoryl)acetate serves as a versatile phosphonylation reagent in synthetic organic chemistry, enabling efficient introduction of the diphenoxyphosphoryl group under mild conditions. Its stability and ease of handling make it well-suited for bench-scale applications, particularly in the synthesis of phosphorylated building blocks and heterocyclic scaffolds. The molecule exhibits good functional group tolerance and facilitates clean transformations in standard reaction protocols.

Synthesis

  • Route1
    • In-stock
      Diphenyl phosphite|CS-0127973
      4712-55-4
    • null|null
      105-36-2
    • ~86%
    • In-stock
      Ethyl 2-(diphenoxyphosphoryl)acetate|CS-0041016
      16139-79-0

    References

    • Olpp, Thomas; Brueckner, Reinhard Synthesis, 2004 , # 13 p. 2135 - 2152
  • Route2
    • null|null
      36957-54-7
    • null|null
      108-95-2
    • ~60%
    • In-stock
      Ethyl 2-(diphenoxyphosphoryl)acetate|CS-0041016
      16139-79-0

    References

    • Ando, Kaori Journal of Organic Chemistry, 1997 , vol. 62, # 7 p. 1934 - 1939
  • Route3
    • null|null
      7526-26-3
    • null|null
      541-41-3
    • ~89%
    • In-stock
      Ethyl 2-(diphenoxyphosphoryl)acetate|CS-0041016
      16139-79-0

    References

    • Ando, Kaori Journal of Organic Chemistry, 1999 , vol. 64, # 22 p. 8406 - 8408

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   61.83
  • LogP   3.9006
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   7

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