Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine

  • CAS No. 16097-60-2

  • Cat. No. CS-W018916
  • Purity≥97%
  • MDL No.MFCD06656426

*For research and further manufacturing use only, not for direct human use.

2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine|CS-W018916

Structure of 16097-60-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 16097-60-2
  • Cat. No. CS-W018916
  • Purity ≥97%
  • MDL No. MFCD06656426
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClF₃N₃
  • Molecular Weight 197.55
  • Synonym(s) 4-CHLORO-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-YLAMINE
  • SMILES FC(C1=CC(Cl)=NC(N)=N1)(F)F

Description

2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the amino and chloro substituents enable selective coupling reactions. This pyrimidine scaffold serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and antiviral agents.

Application

2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via nucleophilic substitution and cross-coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the amino and chloro functionalities provide orthogonal handles for sequential derivatization. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for scalable synthesis of kinase inhibitors and other bioactive molecules.

Synthesis

  • Route1

    References

    • Zhao, Yan-Fang; Liu, Zi-Jian; Zhai, Xin; Ge, Dan-Dan; Huang, Qiang; Gong, Ping Chinese Chemical Letters, 2013 , vol. 24, # 5 p. 386 - 388
  • Route2

    References

    • Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
  • Route3
    • null|null
      85730-34-3
    • ~%
    • In-stock
      2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine|CS-W018916
      16097-60-2

    References

    • Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.731
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 16097-60-2 sigma16097-60-2 manufacturer16097-60-2 price16097-60-2 structure16097-60-2 SDSbuy 16097-60-216097-60-2 supplier16097-60-2 uses16097-60-2 molecular weightprice of 16097-60-216097-60-2 chemical name formula of 16097-60-2
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label