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CS-W001157 4
Total: USD 88.00

1-Phenylindole

  • CAS No. 16096-33-6

  • Cat. No. CS-W006833
  • Purity≥95%
  • MDL No.MFCD00123280

*For research and further manufacturing use only, not for direct human use.

1-Phenylindole|CS-W006833

Structure of 16096-33-6

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General Information

  • CAS No. 16096-33-6
  • Cat. No. CS-W006833
  • Purity ≥95%
  • MDL No. MFCD00123280
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₁N
  • Molecular Weight 193.25
  • Synonym(s) None
  • SMILES C=1C=CC(=CC1)N2C=CC=3C=CC=CC32

Description

1-Phenyl-1H-indole features a fused bicyclic core with an appended phenyl group, enhancing π-conjugation and enabling applications in organic synthesis and materials science. This bench-stable heterocycle integrates readily into complex scaffolds, offering predictable reactivity in electrophilic substitution and transition-metal-catalyzed coupling processes.

Application

1-Phenyl-1H-indole serves as a versatile scaffold in medicinal chemistry and materials science, enabling efficient construction of biologically active heterocycles. Its robust indole core exhibits favorable bench stability and compatibility with standard functionalization protocols, including electrophilic substitution and transition-metal-catalyzed coupling reactions. The molecule functions effectively as a building block for pharmaceutical intermediates and fluorescent probes due to its extended π-conjugation and predictable reactivity profile.

Synthesis

  • Route1
    • Indole, ≥99%|CS-1268948
      120-72-9
    • null|null
      108-86-1
    • ~99%
    • In-stock
      1-Phenylindole|CS-W006833
      16096-33-6

    References

    • Grasa; Viciu; Huang; Nolan Journal of Organic Chemistry, 2001 , vol. 66, # 23 p. 7729 - 7737
  • Route2
    • Indole, ≥99%|CS-1268948
      120-72-9
    • null|null
      108-90-7
    • ~98%
    • In-stock
      1-Phenylindole|CS-W006833
      16096-33-6

    References

    • TAKASAGO INTERNATIONAL CORPORATION; NAKAYAMA, Yuji; KOBAYASHI, Tohru Patent: WO2013/32035 A1, 2013 ; Location in patent: Page/Page column 46; 47 ;
  • Route3

    References

    • Tang, Bo-Xiao; Guo, Sheng-Mei; Zhang, Man-Bo; Li, Jin-Heng Synthesis, 2008 , # 11 p. 1707 - 1716

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   4.93
  • LogP   3.6305
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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