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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-isobutoxypropanoic acid

  • CAS No. 1607004-16-9

  • Cat. No. CS-0089040
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-isobutoxypropanoic acid|CS-0089040

Structure of 1607004-16-9

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General Information

  • CAS No. 1607004-16-9
  • Cat. No. CS-0089040
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₅NO₅
  • Molecular Weight 383.44
  • Synonym(s) N-Fmoc-O-isobutyl-L-serine
  • SMILES O=C(O)[C@H](COCC(C)C)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-isobutoxypropanoic acid is a chiral building block featuring a fluorenylmethyl (Fmoc) protecting group and a sterically hindered isobutoxy side chain. This configuration enables reliable incorporation into peptide synthesis workflows, offering enhanced solubility and stability under standard coupling conditions.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-isobutoxypropanoic acid serves as a valuable chiral building block in peptide synthesis, enabling efficient incorporation of sterically hindered, hydrophobic side chains. The Fmoc group provides orthogonal protection for amines, while the isobutoxypropanoyl moiety offers enhanced solubility and stability during solid-phase synthesis. This derivative facilitates sequence-specific coupling reactions with high fidelity and ease of purification, making it well-suited for the construction of complex peptide scaffolds and medicinal chemistry campaigns requiring precise stereochemical control.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   3.6509
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   8

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