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CS-W001157 4
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2-Methoxy-4-methyl-3-nitropyridine

  • CAS No. 160590-36-3

  • Cat. No. CS-0082356
  • Molecule weight168.15
  • Purity≥97%
  • MDL No.MFCD08277286

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-4-methyl-3-nitropyridine|CS-0082356

Structure of 160590-36-3

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General Information

  • CAS No. 160590-36-3
  • Cat. No. CS-0082356
  • Purity ≥97%
  • MDL No. MFCD08277286
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₃
  • Molecular Weight 168.15
  • Synonym(s) 2-Methoxy-3-Nitro-4-Picoline
  • SMILES COC1=NC=CC(C)=C1[N+]([O-])=O

Description

2-Methoxy-4-methyl-3-nitropyridine features a nitro group at C3, flanked by electron-donating methoxy and methyl substituents, creating a uniquely polarized heterocyclic framework. This arrangement enhances regioselective reactivity in cross-coupling and nucleophilic substitution processes, enabling efficient incorporation into functionalized pharmaceutical intermediates and advanced materials.

Application

2-Methoxy-4-methyl-3-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds via selective reduction and coupling reactions. Its orthogonal functional groups—nitro, methoxy, and methyl—support sequential transformations under mild conditions, facilitating the construction of complex nitrogen-containing architectures relevant to medicinal chemistry. The compound exhibits good bench stability and is amenable to purification by standard chromatographic techniques.

Synthesis

  • Route1
    • In-stock
      2-Chloro-4-methyl-3-nitropyridine|CS-W020672
      23056-39-5
    • null|null
      124-41-4
    • ~98%
    • In-stock
      2-Methoxy-4-methyl-3-nitropyridine|CS-0082356
      160590-36-3

    References

    • Evans; Furneaux; Hutchison; Kezar; Morris, Jr.; Schramm; Tyler Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5723 - 5730

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.26
  • LogP   1.30682
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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