Lot numbers can be found on the outside label of a product:
1-Acetyl-4-aminopiperidine
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CAS No. 160357-94-8
- Cat. No. CS-W008618
- Purity≥97%
- MDL No.MFCD03412449
*For research and further manufacturing use only, not for direct human use.
Structure of 160357-94-8
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General Information
- CAS No. 160357-94-8
- Cat. No. CS-W008618
- Purity ≥97%
- MDL No. MFCD03412449
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₁₄N₂O
- Molecular Weight 142.20
- Synonym(s) 1-(4-Amino-1-piperidinyl)ethanone; (1-Acetyl-4-piperidinyl)amine; 1-(4-Aminopiperidin-1-yl)ethanone; 4-Amino-N-1-acetylpiperidine
- SMILES CC(N1CCC(N)CC1)=O
Description
1-Acetyl-4-aminopiperidine is a bench-stable, moisture-tolerant piperidine derivative featuring a strategically positioned acetyl group that enhances solubility and reactivity. This functionalized scaffold integrates readily into medicinal chemistry libraries, enabling efficient access to bioactive analogs through straightforward derivatization pathways.
Application
1-Acetyl-4-aminopiperidine serves as a versatile building block in medicinal chemistry, enabling the construction of diverse piperidine-based scaffolds. The acetyl group provides protection for the amine while maintaining reactivity for subsequent functionalization, and the secondary amine facilitates salt formation and hydrogen bonding. Its bench-stable nature and compatibility with standard coupling and reduction protocols make it well-suited for multi-step synthesis and API development workflows.
Synthesis
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Route1
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135581-16-7 - ~10%
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In-stock
160357-94-8
References
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PFIZER PRODUCTS INC. Patent: WO2004/110996 A1, 2004 ; Location in patent: Page/Page column 102 ; WO 2004/110996 A1
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Route2
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577778-36-0 - ~73%
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In-stock
160357-94-8
References
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Manetti, Dina; Martini, Elisabetta; Ghelardini, Carla; Dei, Silvia; Galeotti, Nicoletta; Guandalini, Luca; Romanelli, Maria Novella; Scapecchi, Serena; Teodori, Elisabetta; Bartolini, Alessandro; Gualtieri, Fulvio Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2303 - 2306
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Route3
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In-stock
283167-28-2 - ~%
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In-stock
160357-94-8
References
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US2008/227780 A1, ; Page/Page column 53-54 ; US 20080227780 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.33
- LogP -0.044
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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