1-(4-Aminopiperidin-1-yl)-2,2,2-trifluoroethan-1-one hydrochloride

Name: 1-(4-Aminopiperidin-1-yl)-2,2,2-trifluoroethan-1-one hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 221340-53-0
Cat. No. CS-0197625
Purity≥97%
MDL No.None

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1-(4-Aminopiperidin-1-yl)-2,2,2-trifluoroethan-1-one hydrochloride|CS-0197625

Structure of 221340-53-0

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General Information

CAS No. 221340-53-0
Cat. No. CS-0197625
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₂ClF₃N₂O
Molecular Weight 232.63
Synonym(s) 1-(4-Aminopiperidin-1-yl)-2,2,2-trifluoroethanone hydrochloride
SMILES Cl.O=C(N1CCC(N)CC1)C(F)(F)F

Description

This trifluoromethyl ketone derivative integrates a piperidinyl amine handle for conjugation, enabling rapid derivatization in synthetic workflows. The hydrochloride salt enhances solubility and stability under standard conditions, supporting efficient incorporation into bioconjugates and pharmaceutical intermediates.

Application

1-(4-Aminopiperidin-1-yl)-2,2,2-trifluoroethan-1-one hydrochloride serves as a versatile building block for medicinal chemistry, enabling the efficient construction of trifluoromethylated piperidine scaffolds. The electrophilic trifluoromethyl ketone moiety reacts readily with amines and hydrazines under mild conditions, facilitating rapid diversification. Its bench-stable solid form and excellent functional group tolerance support scalable synthesis and straightforward purification, making it ideal for high-throughput library generation and target-oriented compound development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

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Computational Chemistry Data

TPSA 46.33
LogP 0.9202
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1-(4-Aminopiperidin-1-yl)-2,2,2-trifluoroethan-1-one hydrochloride

CAS No. 221340-53-0

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