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CS-W001157 4
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5-(Pyrrolidin-1-yl)pyridine-2-carbonitrile

  • CAS No. 160017-09-4

  • Cat. No. CS-0223636
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Pyrrolidin-1-yl)pyridine-2-carbonitrile|CS-0223636

Structure of 160017-09-4

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General Information

  • CAS No. 160017-09-4
  • Cat. No. CS-0223636
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁N₃
  • Molecular Weight 173.21
  • Synonym(s) 5-Pyrrolidin-1-ylpyridine-2-carbonitrile
  • SMILES N#CC1=NC=C(N2CCCC2)C=C1

Description

5-(Pyrrolidin-1-yl)pyridine-2-carbonitrile features a pyrrolidinyl group conjugated to a nitrile-substituted pyridine core, delivering enhanced solubility and electron-rich character. This scaffold integrates readily into transition metal-catalyzed coupling reactions and serves as a key ligand in catalytic systems requiring moderate basicity and π-donating capacity.

Application

5-(Pyrrolidin-1-yl)pyridine-2-carbonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The pyrrolidine moiety enhances solubility and modulates basicity, while the nitrile group provides a handle for downstream functionalization. This compound exhibits excellent bench stability and is compatible with standard synthetic workflows, facilitating rapid diversification in drug discovery campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   39.92
  • LogP   1.55348
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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