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CS-W001157 4
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tert-Butyl 3-hydroxy-4-methylidenepiperidine-1-carboxylate

  • CAS No. 159635-22-0

  • Cat. No. CS-0048283
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-hydroxy-4-methylidenepiperidine-1-carboxylate|CS-0048283

Structure of 159635-22-0

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Description

tert-Butyl 3-hydroxy-4-methylidenepiperidine-1-carboxylate features a rigid piperidine core with a strategically positioned hydroxyl group and exocyclic methylene moiety, enabling direct functionalization at C3 and C4. This scaffold supports efficient access to complex nitrogen heterocycles in medicinal chemistry and natural product synthesis.

Application

tert-Butyl 3-hydroxy-4-methylidenepiperidine-1-carboxylate serves as a versatile scaffold for the synthesis of piperidine-based heterocycles, enabling efficient access to medicinally relevant frameworks. The pendant hydroxyl group facilitates selective derivatization, while the exocyclic methylene moiety supports Diels–Alder reactions and Michael additions. Its tert-butyl carbamate protection offers excellent bench stability and ease of deprotection under mild acidic conditions, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

General Information

  • CAS No. 159635-22-0
  • Cat. No. CS-0048283
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₃
  • Molecular Weight 213.27
  • Synonym(s) Tert-butyl 3-hydroxy-4-methylenepiperidine-1-carboxylate
  • SMILES CC(C)(C)OC(=O)N1CCC(=C)C(O)C1

Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.5443
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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