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3-Bromo-2-methoxy-5-nitropyridine

  • CAS No. 15862-50-7

  • Cat. No. CS-0059269
  • Purity≥97%
  • MDL No.MFCD06659517

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-methoxy-5-nitropyridine|CS-0059269

Structure of 15862-50-7

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General Information

  • CAS No. 15862-50-7
  • Cat. No. CS-0059269
  • Purity ≥97%
  • MDL No. MFCD06659517
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrN₂O₃
  • Molecular Weight 233.02
  • Synonym(s) 3-Bromo-2-Methoxy-5-Nitropyridinr
  • SMILES O=[N+](C1=CN=C(OC)C(Br)=C1)[O-]

Description

3-Bromo-2-methoxy-5-nitropyridine features a pyridine core functionalized with bromo, methoxy, and nitro groups at distinct positions, enabling selective cross-coupling and derivatization. The electron-deficient ring facilitates palladium-catalyzed reactions, while the methoxy group enhances solubility and modulates reactivity. This compound serves as a key intermediate in medicinal chemistry and agrochemical synthesis.

Application

3-Bromo-2-methoxy-5-nitropyridine serves as a versatile building block for the synthesis of functionalized pyridine derivatives. The bromo group enables palladium-catalyzed cross-coupling reactions, while the methoxy and nitro substituents provide orthogonal reactivity for further derivatization. Its stability under standard reaction conditions and compatibility with diverse coupling protocols make it a practical choice for medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.26
  • LogP   1.7609
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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