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CS-W001157 4
Total: USD 88.00

4-Chloro-6-methyl-2-trifluoromethylpyrimidine

  • CAS No. 1582-25-8

  • Cat. No. CS-0153157
  • Purity≥98%
  • MDL No.MFCD09743686

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-methyl-2-trifluoromethylpyrimidine|CS-0153157

Structure of 1582-25-8

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General Information

  • CAS No. 1582-25-8
  • Cat. No. CS-0153157
  • Purity ≥98%
  • MDL No. MFCD09743686
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₃N₂
  • Molecular Weight None
  • Synonym(s) 6-Chlor-4-methyl-2-trifluormethylpyrimidin
  • SMILES CC1=CC(=NC(=N1)C(F)(F)F)Cl

Description

4-Chloro-6-methyl-2-trifluoromethylpyrimidine features a trifluoromethyl group at the 2-position and a methyl substituent at the 6-position, conferring enhanced electron-withdrawing character and metabolic stability. This pyrimidine scaffold serves as a key building block in agrochemical and pharmaceutical synthesis, offering high reactivity in cross-coupling and nucleophilic substitution reactions under standard conditions.

Application

4-Chloro-6-methyl-2-trifluoromethylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro and methyl substituents provide orthogonal sites for nucleophilic substitution and further functionalization. The compound exhibits good bench stability and compatibility with standard cross-coupling and amine displacement reactions, facilitating rapid diversification in API discovery workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.45722
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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