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CS-W001157 4
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DOTA-amide

  • CAS No. 157599-02-5

  • Cat. No. CS-0128882
  • Purity≥97%
  • MDL No.MFCD09263318

*For research and further manufacturing use only, not for direct human use.

DOTA-amide|CS-0128882

Structure of 157599-02-5

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General Information

  • CAS No. 157599-02-5
  • Cat. No. CS-0128882
  • Purity ≥97%
  • MDL No. MFCD09263318
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₃₂N₈O₄
  • Molecular Weight 400.48
  • Synonym(s) None
  • SMILES O=C(CN1CCN(CCN(CCN(CC1)CC(N)=O)CC(N)=O)CC(N)=O)N

Description

DOTA-amide delivers a robust, macrocyclic chelating scaffold with high affinity for lanthanide and transition metal ions. This stable complexation platform enables precise radiolabeling in diagnostic imaging and targeted therapeutics, leveraging the amide functionality for enhanced solubility and metabolic resistance under physiological conditions.

Application

DOTA-amide serves as a robust macrocyclic chelator for radiometal coordination, enabling stable conjugation of isotopes such as ⁶⁸Ga, ⁶⁴Cu, and ¹⁵³Gd in bioconjugate applications. Its amide terminus facilitates site-specific coupling to peptides or proteins via standard amidation protocols, offering excellent stability, high functional group tolerance, and straightforward purification—making it ideal for developing PET/SPECT imaging agents and targeted radiotherapeutics.

Synthesis

  • Route1

    References

    • Maumela, Hulisani; Hancock, Robert D.; Carlton, Laurence; Reibenspies, Joseph H.; Wainwright, Kevin P. Journal of the American Chemical Society, 1995 , vol. 117, # 25 p. 6698 - 6707
  • Route2

    References

    • Amin, Shahid; Morrow, Janet R.; Lake, Charles H.; Churchill, Melvyn Rowen Angewandte Chemie, 1994 , vol. 106, # 7 p. 824 - 826

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   185.32
  • LogP   -4.8508
  • H_Acceptors   8
  • H_Donors   4
  • Rotatable_Bonds   8

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