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CS-W001157 4
Total: USD 88.00

2-Methyl-1-naphthoic acid

  • CAS No. 1575-96-8

  • Cat. No. CS-0094386
  • Purity≥96%
  • MDL No.MFCD00089618

*For research and further manufacturing use only, not for direct human use.

2-Methyl-1-naphthoic acid|CS-0094386

Structure of 1575-96-8

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General Information

  • CAS No. 1575-96-8
  • Cat. No. CS-0094386
  • Purity ≥96%
  • MDL No. MFCD00089618
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀O₂
  • Molecular Weight 186.21
  • Synonym(s) 2-METHYLNAPHTHALENE-1-CARBOXYLIC ACID
  • SMILES O=C(C1=C2C=CC=CC2=CC=C1C)O

Description

2-Methyl-1-naphthoic acid is a sterically hindered aromatic carboxylic acid featuring a methyl group at the 2-position of the naphthalene core. This substitution enhances stability and modulates reactivity, making it valuable for synthesizing pharmaceutical intermediates, agrochemicals, and functional materials. The acidic functionality enables direct coupling reactions under standard conditions.

Application

2-Methyl-1-naphthoic acid serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the naphthalene core for pharmaceutical and agrochemical scaffold development. Its carboxylic acid group facilitates amidation, esterification, and coupling reactions under standard conditions, while the methyl substituent provides steric and electronic modulation. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in iterative synthesis workflows and scale-up applications.

Synthesis

  • Route1
    • null|null
      124-38-9
    • null|null
      91-57-6
    • ~95%
    • In-stock
      2-Methyl-1-naphthoic acid|CS-0094386
      1575-96-8

    References

    • Nemoto, Koji; Yoshida, Hiroki; Egusa, Naoki; Morohashi, Naoya; Hattori, Tetsutaro Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7855 - 7862
  • Route2
    • null|null
      124-38-9
    • In-stock
      1-Bromo-2-methylnaphthalene|CS-0128760
      2586-62-1
    • ~99%
    • In-stock
      2-Methyl-1-naphthoic acid|CS-0094386
      1575-96-8

    References

    • Lehmann, Fredrik; Currier, Erika A.; Olsson, Roger; Ma, Jian-Nong; Burstein, Ethan S.; Hacksell, Uli; Luthman, Kristina Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 13 p. 4844 - 4854
  • Route3
    • In-stock
      1-Naphthoic acid|CS-W020013
      86-55-5
    • null|null
      74-88-4
    • ~48%
    • In-stock
      2-Methyl-1-naphthoic acid|CS-0094386
      1575-96-8

    References

    • Tilly, David; Castanet, Anne-Sophie; Mortier, Jacques Chemistry Letters, 2005 , vol. 34, # 3 p. 446 - 447

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.84642
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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