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CS-W001157 4
Total: USD 88.00

1-Naphthoic acid

  • CAS No. 86-55-5

  • Cat. No. CS-W020013
  • Purity≥98%
  • MDL No.MFCD00004007

*For research and further manufacturing use only, not for direct human use.

1-Naphthoic acid|CS-W020013

Structure of 86-55-5

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General Information

  • CAS No. 86-55-5
  • Cat. No. CS-W020013
  • Purity ≥98%
  • MDL No. MFCD00004007
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₈O₂
  • Molecular Weight 172.18
  • Synonym(s) Naphthalene-1-carboxylic acid
  • SMILES O=C(C1=C2C=CC=CC2=CC=C1)O

Description

Benzyl-PEG6-alcohol is a PEG linker with a benzyl protecting group and a primary alcohol. The benzyl protecting group can be removed under acidic conditions. The primary alcohol can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Application

1-Naphthoic acid serves as a versatile building block in organic synthesis, particularly for constructing fused heterocycles and functionalized aromatic systems. Its carboxylic acid group enables direct derivatization via esterification, amidation, or coupling reactions, while the naphthalene scaffold provides structural rigidity and π-conjugation beneficial in pharmaceutical and materials chemistry. The compound exhibits good bench stability and is readily purified by recrystallization, facilitating integration into standard synthetic workflows.

Synthesis

  • Route1

    References

    • Kuwabara, Kiyoto; Itoh, Akichika Synthesis, 2006 , # 12 p. 1949 - 1952
  • Route2
    • null|null
      201230-82-2
    • In-stock
      1-Bromonaphthalene|CS-0017140
      90-11-9
    • ~99%
    • In-stock
      1-Naphthoic acid|CS-W020013
      86-55-5

    References

    • Kudo, Kiyoshi; Shibata, Tadashi; Kashimura, Tsugunori; Mori, Sadayuki; Sugita, Nobuyuki Chemistry Letters, 1987 , p. 577 - 580
  • Route3
    • 2-Hydroxy-1,2-di(naphthalen-1-yl)ethan-1-one|CS-0504813
      39627-76-4
    • ~%
    • In-stock
      1-Naphthoic acid|CS-W020013
      86-55-5

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 21 p. 6716 - 6720

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.538
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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