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CS-W001157 4
Total: USD 88.00

6-chlorophenanthridine

  • CAS No. 15679-03-5

  • Cat. No. CS-W018434
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-chlorophenanthridine|CS-W018434

Structure of 15679-03-5

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General Information

  • CAS No. 15679-03-5
  • Cat. No. CS-W018434
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₈ClN
  • Molecular Weight 213.66
  • Synonym(s) 6-chlorophenidine
  • SMILES ClC1=NC2=CC=CC=C2C3=CC=CC=C31

Description

6-Chlorophenanthridine is a heterocyclic compound featuring a chlorine atom at the 6-position of the phenanthridine core. This substitution enhances electron deficiency, improving its utility in transition metal-catalyzed coupling reactions. The molecule exhibits robust stability under standard bench conditions and integrates readily into synthetic pathways requiring nitrogen-containing scaffolds.

Application

6-Chlorophenanthridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable halogen functionality. Its rigid polycyclic structure provides excellent orthogonality in complex synthesis, while the chlorine substituent facilitates selective functionalization. The compound exhibits good bench stability and is readily purified by column chromatography, making it well-suited for iterative synthetic workflows in API development.

Synthesis

  • Route1

    References

    • National University Corporation Gunma University Patent: US2011/201802 A1, 2011 ; Location in patent: Page/Page column 10 ;
  • Route2

    References

    • Nagesh, Hunsur Nagendra; Suresh, Narva; Mahalakshmi Naidu, Kalaga; Arun, Boyineni; Padma Sridevi, Jonnalagadda; Sriram, Dharmarajan; Yogeeswari, Perumal; Sekhar, Kondapalli Venkata Gowri Chandra European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 333 - 339
  • Route3
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    • ~%
    • In-stock
      6-chlorophenanthridine|CS-W018434
      15679-03-5

    References

    • Currie, Kevin S.; Tennant, George Journal of the Chemical Society, Chemical Communications, 1995 , # 22 p. 2295 - 2296

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   4.0414
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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