Lot numbers can be found on the outside label of a product:
6(5H)-Phenanthridinone
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CAS No. 1015-89-0
- Cat. No. CS-0019648
- Purity≥98%
- MDL No.MFCD00004988
*For research and further manufacturing use only, not for direct human use.
Structure of 1015-89-0
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General Information
- CAS No. 1015-89-0
- Cat. No. CS-0019648
- Purity ≥98%
- MDL No. MFCD00004988
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₉NO
- Molecular Weight None
- Synonym(s) None
- SMILES O=C1NC2=CC=CC=C2C3=C1C=CC=C3
Description
6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.Reactant involved in:Synthesis of 5,6-dihydrophenanthridine sulfonamidesOxidative coupling with diphenylacetyleneDirect copper acetate-catalyzed N-cyclopropylation of cyclic amidesReactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:Potassium channel KV1.3 and IK-1 inhibitorsHIV-1 integrase inhibitors
Synthesis
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Route1
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201230-82-2 -
90-41-5
- ~91%
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In-stock
1015-89-0
References
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Liang, Dongdong; Hu, Ziwei; Peng, Jiangling; Huang, Jinbo; Zhu, Qiang Chemical Communications, 2013 , vol. 49, # 2 p. 173 - 175
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Route2
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10282-57-2 - ~70%
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In-stock
1015-89-0
References
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Bhakuni, Bhagat Singh; Kumar, Amit; Balkrishna, Shah Jaimin; Sheikh, Javeed Ahmed; Konar, Sanjit; Kumar, Sangit Organic Letters, 2012 , vol. 14, # 11 p. 2838 - 2841
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Route3
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![[1,1'-Biphenyl]-2-carboxamide|CS-0463008](https://file.chemscene.com/productPIC/CS-0463008.gif)
13234-79-2 - ~87%
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In-stock
1015-89-0
References
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Gui, Qingwen; Yang, Zhiyong; Chen, Xiang; Liu, Jidan; Tan, Ze; Guo, Ruqing; Yu, Wei Synlett, 2013 , vol. 24, # 8 art. no. ST-2013-W0083-L, p. 1016 - 1020
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Safety Information
Download SDS|
GHS Pictogram :
N/A
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GHS No : N/A
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Signal Word : N/A
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : N/A
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Precautionary Statements : N/A
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Quality Control
Computational Chemistry Data
- TPSA 32.86
- LogP 2.6813
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 0
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