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tert-Butyl 4-(3-hydroxypropyl)tetrahydropyridine-1(2H)-carboxylate

  • CAS No. 156185-63-6

  • Cat. No. CS-D0051
  • Purity≥97%
  • MDL No.MFCD02677712

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(3-hydroxypropyl)tetrahydropyridine-1(2H)-carboxylate|CS-D0051

Structure of 156185-63-6

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General Information

  • CAS No. 156185-63-6
  • Cat. No. CS-D0051
  • Purity ≥97%
  • MDL No. MFCD02677712
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₅NO₃
  • Molecular Weight 243.35
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(CC1)CCCO

Description

tert-Butyl 4-(3-hydroxypropyl)tetrahydropyridine-1(2H)-carboxylate features a bench-stable tetrahydropyridine core bearing a pendant hydroxyl-functionalized alkyl chain. This bifunctional scaffold integrates a protected amine and a reactive alcohol, enabling sequential derivatization in medicinal chemistry campaigns. The tert-butyl ester group ensures compatibility with standard deprotection protocols.

Application

tert-Butyl 4-(3-hydroxypropyl)tetrahydropyridine-1(2H)-carboxylate serves as a versatile scaffold for the synthesis of bioactive heterocycles, enabling efficient access to functionalized tetrahydropyridine cores. The pendant hydroxyl group facilitates downstream derivatization via oxidation, esterification, or ether formation, while the tert-butyl carbamate offers protection and ease of removal under mild acidic conditions. Its bench-stable nature and compatibility with standard coupling and reduction protocols make it a practical building block in medicinal chemistry campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   2.406
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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