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Structure of 1554123-46-4
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5-Fluoro-6-(trifluoromethyl)nicotinic acid features a strategically positioned trifluoromethyl group and fluorine substituent that enhance electron-withdrawal and metabolic stability. This combination imparts strong acidity and favorable solubility under standard conditions, enabling direct incorporation into bioactive scaffolds. The molecule serves as a critical building block for pharmaceutical intermediates, particularly in kinase inhibitors and CNS-targeted compounds where lipophilicity and electronic tuning are essential.
5-Fluoro-6-(trifluoromethyl)nicotinic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient pyridine core facilitates nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the fluorine substituent modulates electronic properties and binding affinity. Bench-stable and readily purified by recrystallization, it functions efficiently in standard amide coupling and esterification protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: