Lot numbers can be found on the outside label of a product:
tert-butyl N-(3-hydroxycyclobutyl)carbamate
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CAS No. 154748-63-7
- Cat. No. CS-W003782
- Purity≥95%
- MDL No.MFCD11501030
*For research and further manufacturing use only, not for direct human use.
Structure of 154748-63-7
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General Information
- CAS No. 154748-63-7
- Cat. No. CS-W003782
- Purity ≥95%
- MDL No. MFCD11501030
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₇NO₃
- Molecular Weight 187.24
- Synonym(s) Tert-butyl 3-hydroxycyclobutylcarbamate
- SMILES OC1CC(C1)NC(=O)OC(C)(C)C
Description
tert-Butyl (3-hydroxycyclobutyl)carbamate features a cyclobutyl scaffold bearing a hydroxyl group at the 3-position and a tert-butyloxycarbonyl-protected amine. This configuration delivers a sterically hindered, bench-stable building block ideal for late-stage functionalization in complex molecule synthesis. The hydroxyl moiety enables selective derivatization, while the carbamate protection ensures compatibility with diverse reaction conditions.
Application
tert-Butyl (3-hydroxycyclobutyl)carbamate serves as a stable, bench-friendly building block for cyclobutane-containing scaffolds in medicinal chemistry. The hydroxyl group enables direct functionalization or protection, while the carbamate moiety facilitates mild deprotection under acidic conditions. It functions effectively in standard coupling and cyclization sequences, offering orthogonal reactivity and excellent compatibility with diverse synthetic transformations.
Synthesis
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Route1
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154748-62-6 - ~79%
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In-stock
154748-63-7
References
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BOEHRINGER INGELHEIM INTERNATIONAL GMBH Patent: WO2006/21544 A1, 2006 ; Location in patent: Page/Page column 48 ; WO 2006/021544 A1
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Route2
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In-stock
23761-23-1 - ~%
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In-stock
154748-63-7
References
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WO2013/107291 A1, ;
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Route3
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130369-04-9 - ~%
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In-stock
154748-63-7
References
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US2013/79324 A1, ; US 20130079324 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 58.56
- LogP 1.0344
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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